New Clinical Trial: A Phase 1 Dose-Escalation Study of the Safety and Pharmacokinetics of LAM-002A Administered Orally in Subjects with Relapsed or Refractory B-cell non-Hodgkin Lymphoma

The Weill Cornell Medicine Lymphoma Program has recently opened a new clinical trial for men and women with previously-treated B-cell non-Hodgkin lymphoma. (B-cell NHL) The study sponsor is LAM Therapeutics, and the principal investigator at Weill Cornell is Sarah Rutherford, M.D.. For more information about the study, please call Rita Gazivoda, RN at 212-746-0702 or e-mail Rita at rig9021@med.cornell.edu.

Study Summary

This clinical trial is for men and women with B-cell non-Hodgkin lymphoma (B-cell NHL) who were previously treated for this disease.

Management of patients with non-Hodgkin lymphoma varies widely depending on histology. Patients with DLBCL who relapse after, or who are not candidates for ASCT, as well as patients with relapsed mantle cell lymphoma, marginal zone lymphoma, follicular lymphoma, and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) are not considered curative with conventional therapies. Therefore management of relapsed and refractory NHL remains an unmet medical need.

This is a Phase 1, single-arm, open-label dose-escalation study of the safety and pharmacokinetics of LAM-002A administered orally in subjects with relapsed or refractory B-cell NHL. There will be a dose-escalation stage and an expansion stage for this study. The study drug will be administered on a twice daily oral dosing regimen with a cycle length of 28 days. Patients will continue on treatment as long as they are responding to therapy and not experiencing unacceptable side effects. All patients will be followed for overall survival every three months via telephone contact during the post-treatment follow-up period.

Key Eligibility

  • Men and women age 18 and older with histologically confirmed diagnosis of B-cell NHL limited to follicular lymphoma, DLBCL, mantle cell lymphoma, marginal zone lymphoma, or CLL/SLL.
  • Prior therapy must have included a rituximab-based chemo-immunotherapy regimen.
  • Detailed eligibility reviewed when you contact the study team.

Author: lymphomaprogram

Located on the Upper East Side of New York City, the Lymphoma Program at Weill Cornell Medical College/NewYork Presbyterian Hospital is internationally recognized for our efforts to enable patients with non-Hodgkin lymphoma, Hodgkin disease and related disorders to have the best possible clinical outcome, including cure when possible.

Post a Comment

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s