In this video from OncLive, Dr. Richard Furman discusses the treatment objectives he looks to achieve when treating CLL patients with ibrutinib.
Author: lymphomaprogram
Located on the Upper East Side of New York City, the Lymphoma Program at Weill Cornell Medical College/NewYork Presbyterian Hospital is internationally recognized for our efforts to enable patients with non-Hodgkin lymphoma, Hodgkin disease and related disorders to have the best possible clinical outcome, including cure when possible.
2016 Update in Lymphoma and Myeloma: A Collaboration Across the Americas
Earlier this month Lymphoma Program clinical and research faculty hosted the 2016 Update in Lymphoma and Myeloma. The program is an interactive series including some didactic lectures on new data, discussion around challenging cases in the new era of targeted lymphoma therapies, and tours of our research labs to help stimulate opportunities for collaboration with a group of Latin American oncologists.
Organized by Dr. Peter Martin the meeting seeks to share experiences in managing complicated lymphomas from oncologists around the world and to form collaborative experiences that may be of mutual benefit to both the series hosts and attendees. During this year’s meeting 25 oncologists from South and Central America flew to New York City to attend. The ultimate goal is to help foster collaboration that will help to improve outcomes for patients all over the world.
Discussing the purpose of the event Dr. Peter Martin said, “We are holding this conference because lymphoma has no borders. Through our work we have developed contacts around the world and we have the opportunity to share our experiences with them to better improve patient care. We hope that they can benefit from our knowledge and experience, and help their patients. We hope to find ways to work with them to gather data and information on patient experiences in other countries, so we can help develop programs that might improve outcomes for all patients.”
Weill Cornell Lymphoma Program Study on Mantle Cell Lymphoma Has Received a Top 10 Clinical Research Forum Achievement Award from a National Clinical Research Organization
Dr. Jia Ruan, lead author of the New England Journal of Medicine study “Lenalidomide plus Rituximab as Initial Treatment for Mantle-Cell Lymphoma,” was in Washington on April 12 at the Clinical Research Forum fifth annual awards ceremony to receive the Top 10 Clinical Research Achievements Award. She also presented the study at the opening plenary session during the 2016 Translational Science meeting.
The 10 winning papers were chosen based on their degree of innovation from a pool of more than 40 nominations from 30 research and academic health centers nationwide.
The multi-center phase 2 study showed that a combination therapy lacking many of the typical debilitating effects of traditional cancer treatment could effectively manage mantle cell lymphoma by inducing remissions in the vast majority of patients.
Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin lymphoma that primarily affects elderly individuals. Initial treatment is not standardized and variable, but usually includes chemotherapy regimens that are generally not curative and may not be tolerated by all patients.
In this ongoing study, treatment with biologic combination of lenalidomide and rituximab led to high response rates and durable remissions in patients with previously untreated MCL, providing an effective alternative to conventional chemotherapy for a broad range of patients.
Thirty-eight patients have been treated on the study with induction and maintenance therapy. Among 36 evaluable patients, 92% responded to treatment, 64% of whom achieved complete response. Eighty-five percent of patients have no evidence of disease progression, and 97% remain alive at the two-year mark. The majority of patients reported a high quality of life as measured by quality-of-life instruments throughout treatment. The most common side effect were asymptomatic low white blood cell counts and transient inflammatory symptoms generally reversible with lenalidomide dose adjustment and supportive care.
“With this frontline treatment, we were able to achieve a very high quality and durable response rate without needing to use chemotherapy,” Ruan said. “It’s very meaningful for the patients who have always been told that their disease is without a cure.”
She thanked all of the patients who participated in the trial, as well as her Weill Cornell Medicine co-investigators: John Leonard M.D., Peter Martin M.D., Morton Coleman M.D., Richard Furman M.D., Paul Christos Dr.P.H. M.S., Orel Katz P.A., Jessica Katz P.A., and Amelyn Rodriguez R.N. Additional collaborators included Dr. Bijal Shah from Moffit Cancer Center, Drs. Steven Schuster and Jakub Svoboda from the University of Pennsylvania Abramson Cancer Center, and Dr. Sonali Smith from the University of Chicago Medical Center.
New Developments in Lymphoma 