Treatment Research Study Available for Untreated Hodgkin Lymphoma

Pilot study of abbreviated chemotherapy based on early positron emission tomography in Hodgkin lymphoma

Update: this study is closed to enrollment. 

Patients in this study will be treated with ABVD (adriamycin, bleomycin, vinblastine and dacarbazine) on Days 1 and 15 of each cycle according to standard treatment guidelines.  The purpose of this study is to determine the progression-free survival at 36 months for patients with Hodgkin lymphoma who achieve a response after one cycle of ABVD chemotherapy.

Click here for more information on this study for people with untreated Hodgkin lymphoma or call June Greenberg, RN at (212) 746-2651.

Click here for the clinical and research profile of Rebecca Elstrom, MD, the physician leading the study at Weill Cornell Medical Center.

Study available for Patients with DLBCL

Phase I/II Trial of Azacytidine + R-CHOP in Diffuse Large B-Cell Lymphoma

Update: this study is closed to enrollment.

Significant progress has been made in treatment of diffuse large B-cell lymphoma (DLBCL), but some patients are still not cured of their disease. Recently, researchers have begun to understand how reversible changes in expression of genes contribute to development of cancer and allow cancer cells to become resistant to the effects of chemotherapy. These reversible changes are termed “epigenetics” since they do not involve mutations in genes themselves.

We are working to take advantage of the reversible nature of these changes by pre-treating patients with azacitidine, a drug which reverses epigenetic changes, before starting standard chemotherapy treatment. In this way, we hope to improve the sensitivity of lymphoma cells to chemotherapy.

Key eligibility:

  • Men and women age 18 and older
  • Diagnosed with Diffuse Large B-Cell Lymphoma (DLBCL)
  • Stage II, III or IV disease
  • No previous treatment
  • Detailed eligibility discussed when you contact the study team

For more information about this study, contact June Greenberg, RN at (212) 746-2651 or email June at jdg2002@med.cornell.edu.

Click here to view all our current trials for lymphoma and other cancers and blood disorders.

 

Journal Of Clinical Oncology Publishes Clinical Trial Results Of VELCADE Combination In Aggressive Subtypes Of Non-Hodgkin Lymphoma

Phase II results of a Weill Cornell-sponsored clinical trial examining VELCADE® (bortezomib) in patients with previously untreated aggressive lymphoma were published in February 2011 in the Journal of Clinical Oncology. The study was designed to examine the efficacy of VELCADE in combination with the current standard of care (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone; R-CHOP) in 76 patients with two aggressive subtypes of lymphoma: mantle cell lymphoma (MCL) or diffuse large B-cell lymphoma (DLBCL).

Dr. John Leonard, the Clinical Director of the Weill Cornell Center for Lymphoma and Myeloma, is the the principal investigator of the study. Click here to read the news release summarizing the results of the study. Click here to read the published research paper in the Journal of Clinical Oncology.