Journal Of Clinical Oncology Publishes Clinical Trial Results Of VELCADE Combination In Aggressive Subtypes Of Non-Hodgkin Lymphoma

Phase II results of a Weill Cornell-sponsored clinical trial examining VELCADE® (bortezomib) in patients with previously untreated aggressive lymphoma were published in February 2011 in the Journal of Clinical Oncology. The study was designed to examine the efficacy of VELCADE in combination with the current standard of care (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone; R-CHOP) in 76 patients with two aggressive subtypes of lymphoma: mantle cell lymphoma (MCL) or diffuse large B-cell lymphoma (DLBCL).

Dr. John Leonard, the Clinical Director of the Weill Cornell Center for Lymphoma and Myeloma, is the the principal investigator of the study. Click here to read the news release summarizing the results of the study. Click here to read the published research paper in the Journal of Clinical Oncology.

Clinical Trial for Patients with Relapsed or Refractory DLBCL

A Phase I/II study of combination epigenetic therapy with azacitidine and vorinostat in patients with relapsed and refractory DLBCL

Update: this study is closed to enrollment. 

Researchers have begun to understand how reversible changes in expression of genes contribute to the development of cancer and allow cancer cells to become resistant to the effects of chemotherapy. These reversible changes are termed “epigenetics” since they do not involve mutations in genes themselves.

In this trial we are studying a combination of 2 drugs that may work by reversing epigenetic changes in patients with diffuse large B-cell lymphoma (DLBCL) that has not responded well to chemotherapy.