Category: Patient Education

REDLAMP 6: Entecavir vs. Lamivudine in Preventing Hepatitis B Reactivation in Untreated DLBCL

Reactivation of the Hepatitis B virus (HBV) can be a serious and life threatening complication for lymphoma patients who receive rituximab based treatment like R-CHOP. In this video Dr. Jia Ruan explained the results from a randomized phase 3 trial published in JAMA (The Journal of the American Medical Association). In this study researchers compared the effectiveness of Entecavir and lamivudine in preventing HBV reactivation and clinically significant hepatitis in patients with DLBCL, who are receiving R-CHOP.

Previous #REDLAMP entries can be viewed on our Youtube channel.

We encourage you to follow the Lymphoma Program on Twitter, Youtube, and Facebook where we will highlight new videos are about research publications as they are released. We also welcome your feedback, suggestions and questions about this project. If you have other questions about our lymphoma program or clinical trials or would like to see one of our lymphoma specialists, please contact us at 646-962-2074.

ASCO 2015: Safety of Idelalisib in B-cell Malignancies: Integrated Analysis of Eight Clinical Trials

Picture3By Richard Furman, MD

Idelalisib is a first in class, selective, oral inhibitor of PI3Kδ approved by the FDA for the treatment of chronic lymphocytic leukemia (CLL) in combination with rituximab and as a monotherapy for patients with follicular lymphoma, who have received at least two prior systemic therapies. A recent study sought to analyze the safety profile of idelalisib in 760 subjects with heavily pre-treated and relapsed CLL, non-Hodgkin lymphoma, and other B-cell malignancies, who received idelalisib alone or as part of a combination therapy. Side effects leading to changes in dosing included transaminase elevations (13%), diarrhea/colitis (11%), and rash. Side effects leading to discontinuation of treatment were rare. Patient’s whose dose was interrupted due to adverse events were frequently able to tolerate dosing upon re-challenge. These data demonstrate that idelalisib was well tolerated in patients as a monotherapy or in combination.

Lymphoma Patient Education Forum – June 29th

The Lymphoma Program at Weill Cornell Medical College invites you to hear from our experts about the latest advances in lymphoma treatment & nutrition:

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