New Findings May Play Role in Development of Future DLBCL Treatments

Researchers from Weill Cornell Medicine led by Dr. Olivier Elemento, recently published results announcing the discovery of thousands of new genes from human samples of lymphoma. Known as IncRNAs these genes produce long non-coding RNAs and are involved in gene regulation. The IncRNAs appear to control whether other genes make proteins. The discovery of these genes could underline the processes of gene regulation that drives lymphomas, while in the future leading to possible targets for new  diffuse large B-cell lymphoma therapies.

“These genes produce long non-coding RNAs, known as lncRNAs. Unlike RNA that produces proteins that enable the body to do its work, the lncRNA appear to switch on — or off — other genes that make proteins, researchers say. They counted 2,632 different forms of these unusual RNA molecules. They also found a substantial number of the same or similar lncRNAs in canine lymphoma.”

The study’s senior author, Dr. Olivier Elemento commented,

“While we don’t know precisely what these molecules are doing, the fact that the majority — about two-thirds — of the long non-coding RNAs we found are expressed exclusively in lymphoma, and that many are found in both human and dog lymphoma, tells us that they are likely playing fundamental roles in this cancer…”

Findings like these exemplify the bench to bedside approach in the Lymphoma Program at Weill Cornell Medicine. Look to this space for future updates on this topic and other advances in the treatment of lymphoma. A full listing of available clinical trials for DLBCL lymphoma can be found on our Joint Clinical Trials website.

#EdForumChat Tweet Chat Recap with Dr. John Leonard

Over the weekend Dr. John Leonard answered questions via Twitter from the Lymphoma Research Foundation under the hashtag #EdForumChat about lymphoma, lymphoma treatment options, and lymphoma research.

In case you were unable to participate an edited transcript of the Tweet Chat is available.

Dr. Leonard can be followed on Twitter @JohnPLeonardMD.

“Improving the Odds”: Clinical Care & Research for Lymphoma Patients

The latest issue of Weill Cornell Medicine, the magazine of Weill Cornell Medical College and Weill Cornell Graduate School of Medical Science, profiled the lymphoma program and the improvements in treatment and better outcomes being developed by our physicians and researchers on behalf of our lymphoma patients. If you turn to page 30 of the reader you can find the full article.

A full list our our open clinical trials is available.

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