Combination Veltuzumab (Anti-CD20) and Fractionated 90Y- Epratuzumab (Anti-CD22) Radioimmunotherapy in Patients with Follicular Lymphoma
Update: this study is closed to enrollment.
Monoclonal antibodies can fight lymphoma by binding to proteins expressed on lymphoma cells and either directly killing or inducing the immune system to kill the tumor cells.
With radioimmunotherapy, the antibody is labeled with a radioactive molecule, allowing directed delivery of radiation to the lymphoma. Radioimmunotherapy is effective in follicular lymphoma, but immune reactions against the radiolabeled antibody have limited the utility of this approach.
In this study, we are evaluating the combination of an unlabeled antibody to one lymphoma-associated protein (CD20) with a radio-labeled antibody to a different lymphoma-associated protein (CD22), in hopes of improving responses. The antibodies are modified to minimize immune responses, and both antibodies will be given in repeated doses in order to increase the total amount of drug administered while limiting side effects.
Eligibility:
- Follicular lymphoma
- No more than 2 prior systemic treatments for non-Hodgkin’s lymphoma
- Detailed eligibility discussed when you contact the study team
For more information, contact June Greenberg, RN at (212) 746-2651 or jdg2002@med.cornell.edu.
Click here to view all lymphoma clinical trials at Weill Cornell Medical Center.
