Category: Clinical Trials

Dr. John Leonard Discusses New Data from PYRAMID Study on Non-Germinal Center B-Cell-Like Subtype Diffuse Large Cell Lymphoma

In this video from the ASCO Post, Lymphoma Program Director, Dr. John Leonard discusses results presented at the 2015 meeting of the American Society of Hematology from the recently completed Pyramid trial.  This multi-center phase II study sought to determine whether R-CHOP was more effective with or without bortezomib in patients with untreated non-germinal center B-cell-like subtype diffuse large cell lymphoma. (non-GCB DLBCL)

The study’s full abstract can be read here.

Dr. Sarah Rutherford Describes Recently Opened Trial for Selinexor and RICE Chemotherapy in relapsed/refractory DLBCL

In this video Dr. Sarah Rutherford discusses a trial for men and women with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), who were not cured by initial treatment with R-CHOP or a similar chemotherapy.

The purpose of this study is to determine the maximum tolerated dose of selinexor when given in combination with rituximab, ifosfamide, carboplatin, and etoposide (RICE) in patients with relapsed or refractory aggressive B-cell lymphomas. This is an open-label, phase 1 trial with a standard dose escalation schema.

Tumor biopsies and peripheral blood will be taken pre- and post-treatment with selinexor to examine the study’s biologic objectives.

Key Eligibility

  • Men and woman greater than or equal to 18 years of age
  • Confirmed diffuse large B-cell lymphoma, double/triple hit lymphoma, indolent lymphomas transformed to DLBCL or other aggressive B-cell lymphoma, and follicular lymphoma grade 3B
  • Treatment with at least two cycles of one prior anthracycline-based regimen administered with curative intent
  • Detailed eligiblity reviewed when you contact the study team

If you’re interested in participating in this trial please call 212-746-2919 for more information. A full listing of DLBCL trials at Weill Cornell Medicine can be found on our clinical trials listing.

Effectiveness of Ibrutinib Treatment in Patients with Relapsed or Refractory CLL/SLL with del17p

Dr. Richard Furman
Dr. Richard Furman

CLL patients with a deletion of chromosome 17p on iFISH demonstrate an aggressive course with rapid disease progression and resistance to chemotherapy. The 17p status had been previously confirmed by iFish a test that examines individual cells for chromosomal changes that are significant in predicting disease outcome The missing portion  of chromosome 17 contains the gene for p53, which is one of the most important tumor suppressor genes. The Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib has demonstrated efficacy for patients with the del17p and been approved by the FDA.

In this trial, CLL patients with del17p received ibrutinib once daily until disease progression or unacceptable toxicity.  63% of patients were Rai stage III or IV and 39% had received ≥3 prior therapies. At the median follow-up of 11.5 months, the overall response rate  for all patients was 83%, with a 12 month progression free survival and overall survival  of 79% and 84% respectively.

These results provide further evidence of ibrutinib’s efficacy in prolonging the survival of high risk patients. For more information about available trials for CLL/SLL at Weill Cornell Medicine please follow the link to our new clinical trials listing.